abstract：OBJECTIVE:11beta-Hydroxylase and aldosterone synthase are two highly homologous genes involved in different forms of human hypertension and in different animal models of hypertension. It has been shown that the conservative substitution D147E in the human CYP11B2 gene results in an increased production of corticosteron...

journal_title：European journal of endocrinology

authors： Mulatero P,Glorioso N,Fallo F,Soro A,Morra di Cella S,Carra R,Filigheddu F,Veglio F

更新日期：2001-04-01 00:00:00

abstract：:The aim of this review was to examine the evidence for age-related changes of the hypothalamic-pituitary-adrenal (HPA) axis in both physiological and pathological aging, on the basis of the many data in the literature, as well as of our personal findings. A statistically significant circadian rhythmicity of serum cort...

journal_title：European journal of endocrinology

authors： Ferrari E,Cravello L,Muzzoni B,Casarotti D,Paltro M,Solerte SB,Fioravanti M,Cuzzoni G,Pontiggia B,Magri F

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:The alpha(2)-adrenergic receptors are involved in the effects of catecholamines on energy metabolism. Of three known subtypes with differential expression, alpha(2A)-adrenergic receptors are also localized in adipose tissue where they counteract the lipolytic activity of beta-adrenergic receptors. This study ...

journal_title：European journal of endocrinology

authors： Hamann A,Brieske C,Tafel J,Buttron P,Schwarzloh B,Münzberg H,Hinney A,Mayer H,Siegfried W,Hebebrand J,Greten H,Algenstaedt P,Ziegler R

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:Non-thyroidal illness (NTI) is associated with alterations in thyroid hormone metabolism. Whether morphological changes of the thyroid gland accompany NTI is unknown. The aim of the present study was to describe thyroid morphology in patients with lethal non-thyroidal disease. DESIGN:In an autopsy study 267 ...

journal_title：European journal of endocrinology

authors： De Jongh FE,Jöbsis AC,Elte JW

更新日期：2001-03-01 00:00:00

abstract：OBJECTIVE:The acute decrease in iodide organification in the thyroid in response to excess iodide is termed the acute Wolff-Chaikoff effect and normal organification resumes in spite of continued high plasma iodide concentrations (escape from the acute Wolff-Chaikoff effect). We have recently reported that large doses ...

journal_title：European journal of endocrinology

authors： Eng PH,Cardona GR,Previti MC,Chin WW,Braverman LE

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:It is well established that ovarian steroids modulate gonadotropin secretion from anterior pituitary cells. It has been speculated that insulin and IGF-I might influence gonadotropin secretion. OBJECTIVE:To investigate the effects of IGF-I and estradiol alone, or combinations of IGF-I with insulin and estra...

journal_title：European journal of endocrinology

authors： Xia YX,Weiss JM,Polack S,Diedrich K,Ortmann O

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:Subclinical hypothyroidism occurs in a number of children with Down's syndrome (DS). The reason for the mildly elevated plasma thyrotropin (TSH) concentrations is not known. The present study investigated whether decreased TSH bioactivity plays a role in this phenomenon. DESIGN:A retrospective study of plasm...

journal_title：European journal of endocrinology

authors： Konings CH,van Trotsenburg AS,Ris-Stalpers C,Vulsma T,Wiedijk BM,de Vijlder JJ

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To determine if human growth hormone (hGH) replacement therapy alters pharmacokinetics of hydrocortisone (CS) substitution in hypopituitary adults. DESIGN:To this aim, we analysed serum and salivary CS profiles 270 min after oral CS administration at baseline and 6 and 12 months after initiation of hGH repla...

journal_title：European journal of endocrinology

authors： Tschöp M,Lahner H,Feldmeier H,Grasberger H,Morrison KM,Janssen OE,Attanasio AF,Strasburger CJ

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:To correlate anthropometric, computed tomography and fat cell data from abdominal regions with the levels of serum insulin, C-peptide, leptin, tumor necrosis factor-alpha (TNF-alpha), testosterone, 17beta-estradiol, androstenedione, dehydroepiandrosterone sulphate (DHEA-S) and sex hormone-binding globulin (SH...

journal_title：European journal of endocrinology

authors： Garaulet M,Pérex-Llamas F,Fuente T,Zamora S,Tebar FJ

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:Slow-release (SR) lanreotide is a long-acting somatostatin analog that has been developed in order to overcome the inconvenience of multiple daily subcutaneous injections of octreotide, required for metabolic control in acromegaly. Lanreotide SR has been found to be well tolerated and effective in reducing GH...

journal_title：European journal of endocrinology

authors： Verhelst JA,Pedroncelli AM,Abs R,Montini M,Vandeweghe MV,Albani G,Maiter D,Pagani MD,Legros JJ,Gianola D,Bex M,Poppe K,Mockel J,Pagani G

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:To examine local actions of nitric oxide (NO) on the neural mechanisms controlling the release of vasopressin (AVP) and the cardiovascular system in the anteroventral third ventricular region (AV3V), a pivotal area for autonomic functions, and to pursue the problem of whether it may have any role in the AVP a...

journal_title：European journal of endocrinology

authors： Yamaguchi K,Watanabe K,Yamaya K

更新日期：2000-10-01 00:00:00

abstract：:Gene therapy for endocrine diseases represents an exciting new type of molecular intervention that may be a curative one. Endocrine disorders that might be treated by gene therapy include monogenic diseases, such as GH deficiency and hypothalamic diabetes insipidus, and multifactorial diseases, such as diabetes mellit...

journal_title：European journal of endocrinology

authors： Barzon L,Bonaguro R,Palù G,Boscaro M

更新日期：2000-10-01 00:00:00

abstract：OBJECTIVE:To assess the LH response of the pituitary gland to GnRH stimulation in healthy women with a mutant beta-subunit (Trp8 to Arg8 and Ile15 to Thr15). DESIGN:Clinical study. PATIENTS:We studied 40 healthy non-pregnant Japanese women of known zygosity for the LH beta-subunit gene (3 homozygotes for the mutant g...

journal_title：European journal of endocrinology

authors： Takahashi K,Kurioka H,Ozaki T,Kanasaki H,Miyazaki K,Karino K

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:Prolactin is capable of both trophic and lytic actions in rat corpora lutea. In corpora lutea responding to a trophic prolactin signal, the long form of the prolactin receptor is the dominant form and is upregulated by prolactin. We investigated whether mRNA for the short form of the prolactin receptor was do...

journal_title：European journal of endocrinology

authors： Bowen JM,Telleria CM,Towns R,Keyes PL

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:A sex difference in fetal and neonatal pituitary-gonadal function has been well documented. The aim of the following study was to determine sex differences and patterns of basal LH/FSH in the neonatal period. DESIGN:Peripheral venous blood was obtained from 164 healthy full term newborns (91 males, 73 female...

journal_title：European journal of endocrinology

authors： Schmidt H,Schwarz HP

更新日期：2000-08-01 00:00:00

abstract：OBJECTIVE:We have studied the effect of tryptophan on cellular [(125)I]tri-iodothyronine (T3) uptake by mouse thymocytes. MATERIALS AND METHODS:Mouse thymocytes (20 x 10(6 )cells/ml) were suspended in Krebs-Ringer solution buffered by Tris-HCl and incubation (23 degrees C at pH7.45+/-0.6), in the presence or absence o...

journal_title：European journal of endocrinology

authors： Centanni M,Canettieri G,Viceconti N,Sibilla R,Bei A,Andreoli M

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:Investigation of small numbers of parathyroid tumours by X-chromosome inactivation analysis suggests that the majority of them are monoclonal lesions most likely caused by a somatic mutation. Somatic mutations in the MEN1 gene located on chromosome 11q13 have recently been identified in 12-17% of solitary pa...

journal_title：European journal of endocrinology

authors： Miedlich S,Krohn K,Lamesch P,Müller A,Paschke R

更新日期：2000-07-01 00:00:00

abstract：:Vasoactive and angiogenic factors are involved in the autocrine/paracrine thyroid regulation of microvascular bed during goiter development. In the thyroid of old mice, the presence of slowly functioning ('cold') follicles allowed us to study the microvascular regulation of each follicle in correlation with the immuno...

journal_title：European journal of endocrinology

authors： Gérard AC,Xhenseval V,Colin IM,Many MC,Denef JF

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:In a preliminary cross-sectional study, we discovered that DNA topoisomerase II autoantibodies (anti-TopII) were detected in 49.2% of 195 Chinese type 1 diabetes mellitus (type 1 DM) patients with a mean age of 14.5 years and a mean duration of disease of 4.6 years. In order to demonstrate the relationship be...

journal_title：European journal of endocrinology

authors： Shiau MY,Tsai ST,Hwang J,Wu CY,Chang YH

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of the growth factor activin A on the secretion of prolactin (PRL) and GH in cultured GH3 cells. METHODS:The concentrations of PRL and GH secreted from GH3 cells cultured in media with and without activin A were measured by RIA, and the expression of PRL mRNA and GH mRNA were analyzed ...

journal_title：European journal of endocrinology

authors： Tamura N,Irahara M,Kuwahara A,Ushigoe K,Sugino H,Aono T

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the impact of long-term, non-suppressive levothyroxine (L-T(4)) treatment on quantitative ultrasonometry in women. DESIGN:This was a case-control study. SUBJECTS AND METHODS:Altogether 667 women (mean age+/-s.d., 49.5+/-13.1 years) were studied. Of these, 156 (23%) had non-toxic goitre or hypoth...

journal_title：European journal of endocrinology

authors： Hadji P,Hars O,Sturm G,Bauer T,Emons G,Schulz KD

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To investigate the frequencies of the major maturity-onset diabetes of the young (MODY) subtypes in a panel of Spanish families and to assess phenotypic differences in patients with the different subtypes of MODY. METHODS:Forty-eight subjects from twenty families with clinical diagnosis of MODY were studied....

journal_title：European journal of endocrinology

authors： Costa A,Bescós M,Velho G,Chêvre J,Vidal J,Sesmilo G,Bellanné-Chantelot C,Froguel P,Casamitjana R,Rivera-Fillat F,Gomis R,Conget I

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:To study the contribution of a normal intake of nutrients to the variability of serum leptin concentrations in persons with type 1 diabetes mellitus. DESIGN:We studied the relation between serum leptin and nutrient intake in a cross-sectional study. METHODS:Serum leptin measured by radioimmunoassay, nutriti...

journal_title：European journal of endocrinology

authors： Rojo-Martínez G,Soriguer FJ,González-Romero S,Tinahones F,Moreno F,de Adana SR,Garriga MJ,Esteva I,García-Arnés J,Gómez-Zumaquero JM,García-Almeida JM

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Leptin secretion is reduced by low temperatures in experimental animals, and this effect has been explained as an adaptive mechanism to cold environments. This study investigated the in vitro effects of cold exposure on human white adipose tissue. DESIGN:To understand whether the low temperature action is a ...

journal_title：European journal of endocrinology

authors： Peinó R,Piñeiro V,Gualillo O,Menéndez C,Brenlla J,Casabiell X,Diéguez C,Casanueva FF

更新日期：2000-02-01 00:00:00

abstract：:Multiple endocrine neoplasia type 1 (MEN 1) is a familial syndrome characterized by parathyroid, enteropancreatic and pituitary tumors. The gene responsible for this syndrome is localized at chromosomal 11q13 region and DNA markers from this region cosegregate with the disease. The recent identification of the MEN1 ge...

journal_title：European journal of endocrinology

authors： Morelli A,Falchetti A,Martineti V,Becherini L,Mark M,Friedman E,Brandi ML

更新日期：2000-02-01 00:00:00

abstract：:To evaluate the effects of two regimens of recombinant human GH (rhGH) on growth, bone growth and bone mineralization in GH deficient children, we studied two groups (A and B), each including 16 GH deficient children matched for sex, age, body mass index, height, height velocity and bone age/chronological age ratio (B...

journal_title：European journal of endocrinology

authors： Radetti G,Buzi F,Paganini C,Martelli C,Adami S

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:We measured the total and nonphosphorylated insulin-like growth factor-binding protein (IGFBP)-1 concentrations in obese children to determine the effect of obesity on the status of IGFBP-1 phosphorylation. We also measured the serum levels of insulin, total and free IGF-I, and IGFBP-3 to investigate their re...

journal_title：European journal of endocrinology

authors： Kamoda T,Saitoh H,Nakahara S,Inudoh M,Hirano T,Matsui A

更新日期：1999-12-01 00:00:00

abstract：:Two experiments were conducted to determine the patterns of LH secretion and to evaluate the LH responses to pulsatile administration of GnRH during early pregnancy in ewes. In experiment 1, pregnant ewes (n=16) were used to determine the concentration of LH in plasma of jugular blood samples collected every 15 min fo...

journal_title：European journal of endocrinology

authors： Al-Gubory KH

更新日期：1999-11-01 00:00:00

abstract：:The expression of the neuropeptide Y (NPY) gene varies considerably in human pheochromocytomas, but the mechanisms for this variation have not been clarified. To investigate the regulation pattern of the NPY gene in human pheochromocytomas, we screened 16 pheochromocytomas and 9 normal adrenal tissues with Northern bl...

journal_title：European journal of endocrinology

authors： Liu J,Kahri AI,Heikkilä P,Voutilainen R

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:In type I diabetes mellitus, early markers of beta cell damage are needed in order to detect the infraclinical development of the disease. The reg protein may be a good candidate, as the reg gene has been proposed to play a role in the pancreatic beta cell destruction/regeneration process during diabetogenesi...

journal_title：European journal of endocrinology

authors： Christofilis MA,Carrere J,Atlan-Gepner C,Zevaco-Mattei C,Thivolet C,Baeza N,Figarella C,Vialettes B

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:In order to better understand how the IGF-I axis is affected by exogenous IGF-I, this study compared the effects of a constant s.c. infusion of IGF-I with that of twice-daily injections of IGF-I in young adult female rhesus monkeys. Clinical studies suggest that circulating concentrations of insulin-like grow...

journal_title：European journal of endocrinology

authors： Wilson ME,Lackey SL

更新日期：1999-09-01 00:00:00

abstract：:We report one patient with 21-hydroxylase deficiency and associated bilateral macro-orchidism caused by nodular hyperplasia of testicular adrenal rests (TAR). The boy, referred to us when 10 years old, was born with bilateral cryptorchidism that was treated unsuccessfully with i.m. injections of human chorionic gonado...

journal_title：European journal of endocrinology

authors： Benvenga S,Smedile G,Lo Giudice F,Trimarchi F

更新日期：1999-09-01 00:00:00

abstract：:The effects of water deprivation for 3 days were studied in pregnant rats and their fetuses on day 21 of gestation. Maternal water deprivation induced a significant decrease of the body weight in both maternal and fetal rats. This weight loss was accompanied by significant increases in plasma osmolality and haematocri...

journal_title：European journal of endocrinology

authors： Deloof S,De Seze C,Montel V,Chatelain A

更新日期：1999-08-01 00:00:00

abstract：OBJECTIVE:Dehydroepiandrosterone (DHEA) is a widely studied steroid hormone with multi-functional properties. Reports suggest that some of the many activities of DHEA are due to its protective effect against lipid peroxidation. Nevertheless, the antioxidant properties of DHEA are still the subject of debate. The aim wa...

journal_title：European journal of endocrinology

authors： Gallo M,Aragno M,Gatto V,Tamagno E,Brignardello E,Manti R,Danni O,Boccuzzi G

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:In order to characterize urinary gonadotropin peptide (UGP) as an acute phase reactant, we focused on the UGP levels after surgical operation. DESIGN:Fifty cases of gastrointestinal cancer, 4 cases of cancers of other organs and 13 cases of benign digestive diseases were enrolled into this study. METHODS:UG...

journal_title：European journal of endocrinology

authors： Motoo Y,Watanabe H,Okai T,Sawabu N

更新日期：1999-06-01 00:00:00

abstract：OBJECTIVE:Amine precursor uptake and decarboxylation is a classical feature of gastroenteropancreatic (GEP) neuroendocrine tumors (NET). Production of catecholamines was studied in GEP NET and non-NET patients. DESIGN:A cross-sectional study was undertaken. METHODS:We studied catecholamine and metabolite secretion in...

journal_title：European journal of endocrinology

authors： Ciofu A,Baudin E,Chanson P,Cailleux AF,Comoy E,Sabourin JC,Ducreux M,Schaison G,Schlumberger M

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to investigate whether patients with cystic fibrosis (CF) are GH resistant with increased GH release and decreased concentrations of IGF-I as a result of malabsorption, increased catabolism and impaired glucose tolerance. DESIGN:Twenty CF patients were included, ten with norm...

journal_title：European journal of endocrinology

authors： Laursen EM,Lanng S,Rasmussen MH,Koch C,Skakkebaek NE,Müller J

更新日期：1999-04-01 00:00:00

abstract：:Amiodarone (AMD) is a powerful anti-arrhythmic drug used for the treatment of a wide variety of cardiac arrhythmias and its most striking feature is its high iodine content. Thyroid dysfunction is a limiting side-effect of the drug and both AMD-induced hypothyroidism (AIH) and AMD-induced thyrotoxicosis (AIT) are repo...

journal_title：European journal of endocrinology

authors： Pitsiavas V,Smerdely P,Boyages SC

更新日期：1999-03-01 00:00:00

abstract：:Several cytokines have been shown to be expressed in normal and adenomatous pituitary tissue. Recently, interleukin-8 (IL-8) mRNA was identified by reverse transcription (RT)-PCR in each of a series of 17 pituitary tumours examined. We have investigated further the presence of IL-8 mRNA, using in situ hybridisation in...

journal_title：European journal of endocrinology

authors： Suliman ME,Royds JA,Baxter L,Timperley WR,Cullen DR,Jones TH

更新日期：1999-02-01 00:00:00

abstract：:Congenital generalized lipoatrophy (CGL) is a syndrome with multiple clinical manifestations and complete atrophy of adipose tissue. The exact mechanism of this disease remains unknown. One hypothesis presupposes an abnormal development of adipocytes. Leptin, the adipocyte-specific product of the ob gene, acts as a re...

journal_title：European journal of endocrinology

authors： Jaquet D,Khallouf E,Lévy-Marchal C,Czernichow P

更新日期：1999-01-01 00:00:00